Scientific Effect
Biotin is a B vitamin, heavily involved in human metabolism. Deficiency negatively affects hair and skin. Supplementation may improve cardiovascular and muscle health.
Clinical Study
Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia.
Results
"Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia."
Study Citation
Revilla-Monsalve, C., Zendejas-Ruiz, I., Islas-Andrade, S., Báez-Saldaña, A., Palomino-Garibay, M. A., Hernández-Quiróz, P. M., & Fernandez-Mejia, C. (2006). Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia. Biomedicine & pharmacotherapy, 60(4), 182-185.
LinkClinical Study
High-dose biotin achieves sustained reversal of multiple sclerosis-related disability in a subset of patients with progressive MS
Results
"MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study."
Study Citation
Tourbah, A., Lebrun-Frenay, C., Edan, G., Clanet, M., Papeix, C., Vukusic, S., ... & Defer, G. (2016). MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: a randomised, double-blind, placebo-controlled study. Multiple Sclerosis Journal, 22(13), 1719-1731.
LinkClinical Study
...biotin administration is one choice to relieve hemodialysis patients from muscle cramps regardless of their elevated plasma biotin levels.
Results
"Biotin ameliorates muscle cramps of hemodialysis patients: a prospective trial."
Study Citation
Oguma, S., Ando, I., Hirose, T., Totsune, K., Sekino, H., Sato, H., ... & Fujiwara, M. (2012). Biotin ameliorates muscle cramps of hemodialysis patients: a prospective trial. The Tohoku journal of experimental medicine, 227(3), 217-223.
Link