Melatonin




Scientific Effect

Melatonin is a natural hormone that regulates the sleep-wake cycle. It can increase sleep quality and duration. Its role in the brain makes it effective versus migraines.



Clinical Study

Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention.

Results

"Melatonin 3 mg is better than placebo for migraine prevention, more tolerable than amitriptyline and as effective as amitriptyline 25 mg."

Study Citation

Gonçalves, A. L., Ferreira, A. M., Ribeiro, R. T., Zukerman, E., Cipolla-Neto, J., & Peres, M. F. P. (2016). Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention. J Neurol Neurosurg Psychiatry, 87(10), 1127-1132.

Link


Clinical Study

Melatonin supplementation is a safe and effective way to improve the sleep-onset latency and disease severity in children with Atopic Dermatitis.

Results

"Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial."

Study Citation

Ebrahimi-Monfared, M., Sharafkhah, M., Abdolrazaghnejad, A., Mohammadbeigi, A., & Faraji, F. (2017). Use of melatonin versus valproic acid in prophylaxis of migraine patients: a double-blind randomized clinical trial. Restorative neurology and neuroscience, 35(4), 385-393.

Link


Clinical Study

Pediatric-appropriate, prolonged-release melatonin minitablets was efficacious and safe for treatment of insomnia in children and adolescents with autism spectrum disorder with/without attention-deficit/hyperactivity disorder and neurogenetic disorders.

Results

"Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder."

Study Citation

Gringras, P., Nir, T., Breddy, J., Frydman-Marom, A., & Findling, R. L. (2017). Efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 56(11), 948-957.

Link