Melatonin is a natural hormone that regulates the sleep-wake cycle. It can increase sleep quality and duration. Its role in the brain makes it effective versus migraines.
Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention.
"Melatonin 3 mg is better than placebo for migraine prevention, more tolerable than amitriptyline and as effective as amitriptyline 25 mg."
Gonçalves, A. L., Ferreira, A. M., Ribeiro, R. T., Zukerman, E., Cipolla-Neto, J., & Peres, M. F. P. (2016). Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention. J Neurol Neurosurg Psychiatry, 87(10), 1127-1132.Link
Melatonin supplementation is a safe and effective way to improve the sleep-onset latency and disease severity in children with Atopic Dermatitis.
"Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial."
Ebrahimi-Monfared, M., Sharafkhah, M., Abdolrazaghnejad, A., Mohammadbeigi, A., & Faraji, F. (2017). Use of melatonin versus valproic acid in prophylaxis of migraine patients: a double-blind randomized clinical trial. Restorative neurology and neuroscience, 35(4), 385-393.Link
Pediatric-appropriate, prolonged-release melatonin minitablets was efficacious and safe for treatment of insomnia in children and adolescents with autism spectrum disorder with/without attention-deficit/hyperactivity disorder and neurogenetic disorders.
"Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder."
Gringras, P., Nir, T., Breddy, J., Frydman-Marom, A., & Findling, R. L. (2017). Efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 56(11), 948-957.Link