Scientific Effect
A form of Vitamin B12, methylcobalamin is used to treat neuropathy and anemia. Especially import for vegetarians and vegans, it may also improve symptoms of autism in children.
Clinical Study
Effects of acetyl‐L‐carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double‐blind, controlled trial.
Results
"Acetyl‐L‐carnitine is as effective as methylcobalamin in improving clinical symptoms and neurophysiological parameters for patients with diabetic peripheral neuropathy over a 24‐week period with good tolerance."
Study Citation
Li, S., Chen, X., Li, Q., Du, J., Liu, Z., Peng, Y., ... & Zheng, S. (2016). Effects of acetyl‐L‐carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double‐blind, controlled trial. Journal of diabetes investigation, 7(5), 777-785.
LinkClinical Study
Vegetarians are known to be deficient in vitamin B12, due to a lack of dietary animal products, which can elevate plasma total homocysteine (tHcy). Elevated total tHcy can render vegetarians susceptible to cardiovascular disease (CVD)...Methylcobalamin reduced mean baseline plasma tHcy.
Results
"Efficacy of methylcobalamin to normalise elevated homocysteine of vitamin B12 deficient vegetarians: a double blind placebo control study."
Study Citation
Obersby, D., Chappell, D., Tsiami, A. A., & Dunnett, A. (2015). Efficacy of methylcobalamin to normalise elevated homocysteine of vitamin B12 deficient vegetarians: a double blind placebo control study. Current Research in Nutrition and Food Science, 3(3), 187-196.
LinkClinical Study
Methylcobalamin treatment improved clinician-rated symptoms of childhood autism spectrum disorder that were correlated with improvements in measures of methionine metabolism and cellular methylation capacity.
Results
"Randomized, placebo-controlled trial of methyl B12 for children with autism."
Study Citation
Hendren, R. L., James, S. J., Widjaja, F., Lawton, B., Rosenblatt, A., & Bent, S. (2016). Randomized, placebo-controlled trial of methyl B12 for children with autism. Journal of child and adolescent psychopharmacology, 26(9), 774-783.
Link