N-Acetyl Cysteine is commonly used for the treatment of Cystic Fibrosis. Supplementation is been implicated in cognitive and immune health.
Evaluating the Effect of Oral N-acetylcysteine as an Adjuvant Treatment on Clinical Outcomes of Patients with Rheumatoid Arthritis: A Randomized, Double Blind Clinical Trial.
"...oral administration of NAC may be associated with improving health status in Rheumatoid Arthritis patients"
Batooei, M., Tahamoli-Roudsari, A., Basiri, Z., Yasrebifar, F., Shahdoust, M., Eshraghi, A., ... & Ataei, S. (2018). Evaluating the effect of oral N-acetylcysteine as an adjuvant treatment on clinical outcomes of patients with rheumatoid arthritis: a randomized, double blind clinical trial. Reviews on recent clinical trials, 13(2), 132-138.Link
The present study detected improvement in positive, negative, general and total psychopathology symptoms as well as cognitive performance with NAC treatment.
"Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: A double-blind, randomized clinical trial."
Sepehrmanesh, Z., Heidary, M., Akasheh, N., Akbari, H., & Heidary, M. (2018). Therapeutic effect of adjunctive N-acetyl cysteine (NAC) on symptoms of chronic schizophrenia: a double-blind, randomized clinical trial. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 82, 289-296.Link
...NAC might have some benefit in reducing anxiety symptoms in treatment-resistant OCD patients.
"Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder."
Costa, D. L., Diniz, J. B., Requena, G., Joaquim, M. A., Pittenger, C., Bloch, M. H., ... & Shavitt, R. G. (2017). Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. The Journal of clinical psychiatry, 78(7), e766-e773.Link